Estrogen replacement therapy drugs consist of a synthetic form of estrogen called estradiol. These drugs may be taken orally, subcutaneously, or in this case through a vaginal applicator. The pill dissolves into the lining of the vagina and once inside the cells, estradiol binds to estrogen receptors within the nucleus to initiate physical changes. Overall, this form of estrogen replacement therapy restores vaginal thickness and elasticity, thereby reducing many of the problems associated with vaginal atrophy.
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